How Cigarette Smoking Causes Disease and Amputation of Fingers, Arms, and Legs!

Nicotine itself is not addictive, but it's responsible for releasing dopamine, a neurotransmitter associated with pleasure and reinforcements from the mind, thus inducing addictive tendencies in humans. Nicotine is a chemical found in tobacco leaf, the main ingredient in cigarettes and is said to cause dependence and disease in cigarette smokers, (World Health Organization (WHO)). useful content

Nicotine mimics the actions of acetylcholine, a naturally occurring neurotransmitter in the central nervous system and the nerve-muscle intersection of skeletal muscles. Acetylcholine is responsible for excitability, which induces increase heart rate, endurance, and response times, (Psychopharmacology (Berl). .

Since acetylcholine and nicotine are similar, they activate the identical cholinergic receptors in the brain. The nicotine-acetylcholine receptors consist of nerve endings which release dopamine when combined or bind with nicotine or acetylcholine. Receptors are like cups having the exact measurements that will fit a neurotransmitter molecule, like acetylcholine.

The cup itself is lined with nerve endings (tips of neurons). It is these nerve endings that release dopamine once the neurotransmitter acetylcholine binds with all the cup-like acetylcholine receptors (cholinergic receptors).

A strengthening and reward phenomenon of dopamine develops because the dopamine that's released from the nerve endings initiates a sense of delight in somebody's brain. The reinforcement mechanism is initiated when the brain becomes addicted to the pleasure caused by the E Zigarette dopamine that's discharged from the cholinergic receptors. This means that the brain is constantly trying to be pleasured. So, what will happen in the event of cigarette smokers is that they will continue to smoke cigarettes so that the nicotine in the cigarette may cause the release of dopamine in the brain, making them feel happy every time they smoke a cigarette, (Nature Reviews Neuroscience 7, 967-975 (December 2006)).